These include dry skin, lips, and eyes, headache, decreased night vision, and more rarely, benign intracranial hypertension. It may also lead to an increase in liver enzymes and hypertriglyceridemia; the latter may potentially trigger acute pancreatitis. Additionally, isotretinoin is a highly teratogenic agent, especially if used within the first trimester of pregnancy. Vitamins have been implicated to reduce the side effects of isotretinoin although this effect is controversial. Synthetic vitamins are widely used in cosmetics for the prevention and treatment of acne. It was reported that in 100 patients with acne (vs. matched controls), the systemic levels of vitamins A and E were much lower overall; also, the lower the levels of vitamins A and E, the more severe was the acne. It is likely that the blood levels of antioxidants are used up more readily in those with acne, because there is a greater demand to deal with free radicals that are produced during the stress to skin caused by acne. Several forms of vitamin C (ascorbic acid) are used in lotions, creams, serums, and patches. However, active L-ascorbic acid is such an excellent antioxidant that it is inherently unstable, turning brown as it is oxidized to dehydroascorbic acid when exposed to air. Therefore the shelf life of most formulations containing pure vitamin C is short. Vitamin D metabolites may be of importance for growth regulation and various other cellular Perlelux functions in sebaceous glands making the sebaceous glands to be a promising target for therapy with vitamin D analogues. Omega-3 fatty acid is another supplement added to cosmetic products for the treatment of acne. An analysis of several cosmetic products containing omega-3 fatty acid supplements showed no conclusive evidence that these help in the treatment of acne. Hormonal therapies used in acne include ant androgens (androgen receptor-blockers) and agents designed to decrease the endogenous production of androgens by the ovary or adrenal gland, such as estrogens, combination oral contraceptives (OCs), low-dose glucocorticoids, or gonadotrophin-releasing hormone (Groh) agonists. The use of OCs for acne is controversial because of their potential side effects. Knowing that you are not the only one inflicted with acne at some point in life or another helps as with a better understanding of acne, emerging drugs show potential for the future.

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